Oscar E. Streeter, Jr., M.D.

• Clinical Interests: Breast, head and neck, gastrointestinal malignancies, lymphomas, 3-D treatment of prostate cancer using multi-leaf collimators and high dose rate brachytherapy, sarcomas, and virtual simulations.

• Research Interests: Recruitment and outcome analysis of patients to clinical trials, improved recruitment of women and underrepresented groups to clinical trials, high-dose rate brachytherapy to local regional sites and situations including prostate, recurrent colorectal, esophagus, lung carcinomas, and sarcomas. Three-dimensional treatment planning using a Power PC-based program linked to our CT scanner by Ethernet for conformal treatment of tumors with increased dose of radiation. Socioeconomic factors and how they affect access to quality care.

  Clinical investigations focus on head and neck, lung, and GI tumors using altered fractionation therapy as well as combined modality protocols. We have developed an expertise with orthopedic oncology for treating large sarcomas with limb salvage using high-dose rate brachytherapy as a boost. Wtih medical oncology, we are currently measuring the biological response of esophageal tumors to therapy by examining serially during chemo-radiation treatment ERCC-1 and thymidylate synthase levels. For head and neck tumors we are part of a national trial to use the monoclonal antibody (C225) to the growth factor for head and neck cancers (EGFr) in a randomized trial of Radiation and C225 vs. radiation alone. With our physics division, we are interested in the application of computer-generated fields coming with multiple angles to treat lung cancer in a dose escalation trial of Navelbine and Cisplatin with escalating doses of radiation therapy using PET (positron emission tomography) to assist in defining the biological tumor volume .